Deep brain optogenetics without intracranial surgery
نویسندگان
چکیده
منابع مشابه
Optogenetics and deep brain stimulation neurotechnologies.
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines light and genetic methods to control or monitor neural activity patterns, has proven to be revolutionary in understanding the functional role ...
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quaternary structure of G protein-coupled receptors. FEBS J. 272:2914–2925 Stein C, Schafer M,Machelska H (2003) Attacking pain at its source: new perspectives on opioids. Nat Med 9:1003–1008 Waldhoer M, Bartlett SE, Whistler JL (2004) Opioid receptors. Annu Rev Biochem 73:953–990 Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol R...
متن کاملNear-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecu...
متن کاملOptogenetics: Control of Brain Using Light
Neuronal cells communicate with each other by producing electrical signals or action potentials (APs). Different ion channels, including Na+, K+ and Ca2+ channels, are involved in generation of AP. Once an AP is generated in the soma, it travels down entire the axon length toward its terminal in a self-generating fashion that ultimately conveys information between neurons in the neural circuit....
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2020
ISSN: 1087-0156,1546-1696
DOI: 10.1038/s41587-020-0679-9